Skip Navigation LinksHome > March 2008 - Volume 51 - Issue 1 > Genetic Factors in Common Obstetric Disorders
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e3181616545
Current Concepts in Prenatal Genetics

Genetic Factors in Common Obstetric Disorders

WARD, KENNETH MD* †

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Abstract

Genetic research of disease has recently turned from individual genes for rare but highly penetrant diseases (like cystic fibrosis) to focus on common, multigene disorders with polygenic inheritance patterns, such as preterm labor, preeclampsia, gestational diabetes, placental abruption, and thromboembolism. These conditions are characterized by multiple etiologies, chronicity, fetal involvement, adaptive clinical manifestations, and gene-environment interactions. As we understand genetic contributions to complex disease and build upon the genetic data and technology available, more effective and specific management and treatment options will become available for clinicians and their patients.

© 2008 Lippincott Williams & Wilkins, Inc.

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