Injectable contraceptive methods are safe, highly efficacious, and commonly used worldwide. Depo-Provera (depot-medroxyprogesterone acetate) is the most commonly used injectable in the United States. It is a convenient, discrete, and low-maintenance method, and is ideal for patients with contraindications to estrogen use and certain medical conditions. In addition, there are many noncontraceptive benefits to Depo-Provera use. Side effects with this method including irregular bleeding, breast tenderness, weight gain, and the impact on bone mineral density should be taken into consideration when prescribing the method. Other injectables such as Mesigyna and norethindrone enanthate are widely used outside the United States.
*Department of Obstetrics and Gynecology, Beth Israel Deaconess Hospital, Harvard Medical Center, Boston, Massachusetts
†Obstetrics, Gynecology and Reproductive Sciences, San Francisco General Hospital, University of California, San Francisco, California
Correspondence: Philip D. Darney, MD, MSc, Professor and Chief, Obstetrics, Gynecology and Reproductive Sciences, San Francisco General Hospital, University of California, San Francisco, 1001 Potrero Avenue 6D, San Francisco, CA 94110. E-mail: firstname.lastname@example.org