Hypothermia as a Treatment for Birth AsphyxiaSHANKARAN, SEETHA MD*; LAPTOOK, ABBOT R. MD†Clinical Obstetrics & Gynecology: September 2007 - Volume 50 - Issue 3 - pp 624-635 doi: 10.1097/GRF.0b013e31811eba5e Prevention of Birth Injuries Abstract Author Information This chapter will report to the frequency of neonatal hypoxic-ischemic encephalopathy. The pathophysiology and the childhood outcome of encephalopathy due to hypoxia-ischemia will be examined. The limitations of current therapy for this condition and new therapies will be evaluated. Hypothermia seems to offer the most promise as a therapy for neuroprotection in hypoxic-ischemic encephalopathy. The evidence-based trials of hypothermia will be reviewed along with recommendations regarding clinical applications for this therapy and need for long-term follow-up of children receiving this therapy. *Wayne State University, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, Michigan †Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island Correspondence: Seetha Shankaran, MD, Neonatal-Perinatal Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201. E-mail: firstname.lastname@example.org © 2007 Lippincott Williams & Wilkins, Inc.