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Hypothermia as a Treatment for Birth Asphyxia

SHANKARAN, SEETHA MD*; LAPTOOK, ABBOT R. MD

Clinical Obstetrics & Gynecology: September 2007 - Volume 50 - Issue 3 - pp 624-635
doi: 10.1097/GRF.0b013e31811eba5e
Prevention of Birth Injuries

This chapter will report to the frequency of neonatal hypoxic-ischemic encephalopathy. The pathophysiology and the childhood outcome of encephalopathy due to hypoxia-ischemia will be examined. The limitations of current therapy for this condition and new therapies will be evaluated. Hypothermia seems to offer the most promise as a therapy for neuroprotection in hypoxic-ischemic encephalopathy. The evidence-based trials of hypothermia will be reviewed along with recommendations regarding clinical applications for this therapy and need for long-term follow-up of children receiving this therapy.

*Wayne State University, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, Michigan

Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island

Correspondence: Seetha Shankaran, MD, Neonatal-Perinatal Medicine, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201. E-mail: sshankar@med.wayne.edu

© 2007 Lippincott Williams & Wilkins, Inc.