Skip Navigation LinksHome > March 2007 - Volume 50 - Issue 1 > The Metabolic Syndrome in Polycystic Ovary Syndrome
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e31802f3547
The Polycystic Ovary Syndrome

The Metabolic Syndrome in Polycystic Ovary Syndrome

ESSAH, PAULINA A. MD, MS*; WICKHAM, EDMOND P. MD*; NESTLER, JOHN E. MD* †

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Abstract

Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the metabolic syndrome. Early screening for impaired glucose tolerance, even in adolescents, is recommended. Lifestyle modification with increased physical activity and weight reduction remains first-line therapy. Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome.

© 2007 Lippincott Williams & Wilkins, Inc.

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