Pregnancy Considerations in Women With Polycystic Ovary SyndromeLEGRO, RICHARD S. MDClinical Obstetrics & Gynecology: March 2007 - Volume 50 - Issue 1 - pp 295-304 doi: 10.1097/GRF.0b013e31803057ed The Polycystic Ovary Syndrome Abstract Author Information Women with polycystic ovary syndrome (PCOS) are subfecund, and while anovulatory infertility is most likely the primary cause, other factors may contribute. Recent data suggest that women with PCOS are at increased risk for preterm labor, preeclampsia, and gestational diabetes, though the evidence for increased miscarriage rates is less certain. There is no evidence-based schema for achieving pregnancy in women with PCOS, though lifestyle modification, clomiphene citrate, and metformin are the current front line therapies. There are few data to support treatment during pregnancy with metformin in women with PCOS to prevent pregnancy loss or pregnancy complications. Department of Obstetrics and Gynecology, Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania Correspondence: Richard S. Legro, MD, Department of Obstetrics and Gynecology, 500 University Drive, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033. E-mail: RSL1@psu.edu © 2007 Lippincott Williams & Wilkins, Inc.