Genetics of Polycystic Ovarian SyndromeNAM MENKE, MARIE MD, MPH*; STRAUSS, JEROME F. III MD, PhD†Clinical Obstetrics & Gynecology: March 2007 - Volume 50 - Issue 1 - pp 188-204 doi: 10.1097/GRF.0b013e3180305f7c The Polycystic Ovary Syndrome Abstract Author Information Polycystic ovarian syndrome is a complex disorder with multiple factors affecting its etiology. Elucidation of specific genes and mode of inheritance remains a significant challenge. Linkage and association studies have resulted in over 50 candidate genes as a source of heritable predisposition; however, small sample sizes and failure to reproduce results have hindered efforts. In addition, low fecundity, lack of a male phenotype, and variation of diagnostic criteria represent unique challenges to discovery of polycystic ovarian syndrome genes. A concerted effort will be necessary to conclusively rule in or rule out candidate genes. *Virginia Commonwealth University Health System †Virginia Commonwealth University School of Medicine, Richmond, Virginia This work was supported by the National Institutes of Health (NIH) Grant U54 HD034449. Correspondence: Marie Nam Menke, MD, MPH, Department of Obstetrics and Gynecology, VCUHS, 1101 East Marshall Street, 11th Floor, Sanger Hall, Richmond, VA 23298. E-mail: firstname.lastname@example.org © 2007 Lippincott Williams & Wilkins, Inc.