Skip Navigation LinksHome > March 2007 - Volume 50 - Issue 1 > Genetics of Polycystic Ovarian Syndrome
Clinical Obstetrics & Gynecology:
doi: 10.1097/GRF.0b013e3180305f7c
The Polycystic Ovary Syndrome

Genetics of Polycystic Ovarian Syndrome

NAM MENKE, MARIE MD, MPH*; STRAUSS, JEROME F. III MD, PhD

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Abstract

Polycystic ovarian syndrome is a complex disorder with multiple factors affecting its etiology. Elucidation of specific genes and mode of inheritance remains a significant challenge. Linkage and association studies have resulted in over 50 candidate genes as a source of heritable predisposition; however, small sample sizes and failure to reproduce results have hindered efforts. In addition, low fecundity, lack of a male phenotype, and variation of diagnostic criteria represent unique challenges to discovery of polycystic ovarian syndrome genes. A concerted effort will be necessary to conclusively rule in or rule out candidate genes.

© 2007 Lippincott Williams & Wilkins, Inc.

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