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Laboratory Tests for the Diagnosis of Thrombotic Disorders

MILLER, CONNIE H. PhD

Clinical Obstetrics & Gynecology: December 2006 - Volume 49 - Issue 4 - pp 844-849
doi: 10.1097/01.grf.0000211953.59336.94
Thrombotic Disorders

Diagnosis of thrombotic disorders depends on the performance of a panel of laboratory tests for individual components of the coagulation mechanism. Although genetic tests are simple and accurate, most disorders still require functional or immunologic tests for diagnosis. Tests for the most important thrombotic defects are described. These tests may be significantly altered by pregnancy, hormones, thrombotic events, systemic illness, and anticoagulant therapy. These changes make some thrombotic disorders difficult to diagnose during pregnancy. Testing before pregnancy for women with a personal or family history of thrombosis will simplify the interpretation.

Division of Hereditary Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia

Correspondence: Connie H. Miller, PhD, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop D-02, Atlanta, GA 30345. E-mail: cmiller2@cdc.gov

© 2006 Lippincott Williams & Wilkins, Inc.