Purpose: Charcot–Marie–Tooth Disease type 1A (CMT1A) is caused by a duplication of the peripheral myelin protein gene 22 at chromosome 17p11.2-12. There is limited data regarding whether body mass index (BMI) affects electrophysiological or clinical data in those with CMT1A.
Methods: Electrophysiological data, the Charcot–Marie–Tooth examination score (CMTES) and BMI from 101 patients with known CMT1A were obtained and analyzed.
Results: When controlling for age, a higher BMI does not affect ulnar motor nerve conduction studies in those with CMT1A, but rather components of the CMTES (loss of pinprick and motor strength in the lower extremities).
Conclusions: BMI and clinical components of the CMTES are correlated, but it is uncertain which came first—whether the loss of lower extremity pinprick sensation and motor strength results in a higher BMI or if higher BMI results in these signs.
Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, U.S.A.
Address correspondence and reprint requests to Nivedita U. Jerath, MD, Department of Neurology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, U.S.A.; e-mail: firstname.lastname@example.org.
The authors have no funding or conflicts of interest to disclose.
Supported by a grant from the National Institute of Neurological Disorders and Stroke (M.E.S.) and Office of Rare Diseases (M.E.S., U54NS065712), Muscular Dystrophy Association (M.E.S.), Charcot-Marie-Tooth Association (M.E.S.), and MDA Clinical Research Training grant (N.U.J.).
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