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Evaluation of Cognitive Function When Hearing One's Own Name in Patients With Brain Injuries in Early Developmental Stages

Tamura, Kaori*,†; Mizuba, Takaaki; Okamoto, Tsuyoshi*,†; Matsufuji, Mayumi; Takashima, Sachio; Iramina, Keiji

Journal of Clinical Neurophysiology: May 2017 - Volume 34 - Issue 3 - p 254–260
doi: 10.1097/WNP.0000000000000355
Original Research

Purpose: The level of residual cognitive function in patients with early brain injury is a key factor limiting rehabilitation and the quality of life. Although understanding residual function is necessary for appropriate rehabilitation, the extent of its effects on cognitive improvement remains unknown. This study evaluated cognitive function in patients with severe motor and intellectual disabilities after early brain injuries due to cerebral hemorrhage or periventricular leukomalacia. We focused on neural responses to hearing the subject's own name (SON). According to previous studies, differences in response to SON are associated with several types of cognitive dysfunction.

Methods: We examined healthy subjects (aged 21.4 ± 1.10 years; control) and patients with a previous brain injury (aged 13–27 years at the time of our analysis) resulting in periventricular leukomalacia or a cerebral hemorrhage during the perinatal period or childhood. We recorded EEG responses to the SON and to other Japanese words, obtaining EEG-evoked potentials with wavelet transformations.

Results: Compared with healthy controls, beta power (not alpha power) revealed differences in response to SON by patients with brain injury, especially those with cerebral hemorrhage.

Conclusions: We suggest that alpha and beta power differences reflect different cognitive functions and that the SON response reveals more than one process. Beta powers may reflect the intellectual disability of cognitive function in response to self-relevant stimuli, especially in patients with cerebral hemorrhage. Meanwhile, alpha powers did not differ from those of the healthy controls, suggesting that the patients perhaps paid attention to their own names.

*Faculty of Arts and Science, Kyushu University, Fukuoka, Japan;

Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan; and

Yanagawa Institute for Developmental Disabilities, International University of Health and Welfare Graduate School, Fukuoka, Japan.

Address correspondence and reprint requests to Kaori Tamura, PhD, Faculty of Arts and Science, Kyushu University, 3311, Center 3, 744, Motooka, Nishi-ku, Fukuoka City, Fukuoka, 819-0395, Japan; e-mail: tamura@artsci.kyushu-u.ac.jp.

The authors have no conflicts of interest to disclose.

The authors alone were responsible for the content and writing of this paper.

This work was supported by a Grant-in-Aid for JSPS Fellows (No. 264908) and a Grant-in-Aid for Challenging Exploratory Research (No. 25560287).

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© 2017 by the American Clinical Neurophysiology Society