Skip Navigation LinksHome > June 2012 - Volume 29 - Issue 3 > Approximate Entropy Analysis of Event-Related Potentials in...
Journal of Clinical Neurophysiology:
doi: 10.1097/WNP.0b013e318257ca9d
Original Research

Approximate Entropy Analysis of Event-Related Potentials in Patients With Early Vascular Dementia

Xu, Jin*; Sheng, Hengsong*; Lou, Wutao*; Zhao, Songzhen

Collapse Box

Abstract

Summary: This study investigated differences in event-related potential (ERP) parameters among early vascular dementia (VD) patients, healthy elder controls (ECs), and young controls (YCs). A visual “oddball” color identification task was performed while individuals' electroencephalograms (EEGs) were recorded. Approximate entropy (ApEn), a nonlinear measure, along with P300 latencies and amplitudes were used to analyze ERP data and compare these three groups. The patients with VD showed more complex ERP waveforms and higher ApEn values than did ECs while performing the visual task. It was further found that patients with VD showed reduced P300 amplitudes and increased latencies. The results indicate that patients with VD have fewer attention resources to devote to processing stimuli, lower speed of stimulus classification, and lower synchrony in their cortical activity during the response period. We suggest that ApEn, as a measure of ERP complexity, is a promising marker for early diagnosis of VD.

Copyright © 2012 American Clinical Neurophysiology Society

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.