Purpose: To describe the novel finding of epileptic spasms arising from a cingulate lesion.
Methods: We describe two children presenting with epileptic spasms who had lesions of the cingulate gyrus on MRI.
Results: In both patients, the lesions involved the midcingulate cortex. Seizures were characterized by prominent motor manifestations and resembled spasms. Both patients had a complete resolution of seizures after resection of their cingulate lesions.
Discussion: Cingulate seizures can present with a variety of behaviors including complex motor manifestations, vocalizations, and autonomic changes. Lesions in the midcingulate cortex can also produce epileptic spasms.