Background: Serotonin syndrome is a potentially fatal complication that usually occurs in the combination use of several serotonergic agents. We presented a patient with major depressive disorder under the treatment of bupropion, trazodone, and quetiapine. Serotonin syndrome developed soon after she received the first session of electroconvulsive therapy (ECT).

Method: This study is a case report.

Results: A 70-year-old female with major depressive disorder developed serotonin syndrome after the first session of ECT in combination with bupropion, trazodone, and quetiapine. Serotonin syndrome did not reappear in the subsequent ECT treatment while in the treatment with different therapeutic agents.

Conclusions: The superimposing effect of ECT in conjunction with serotonergic agents might contribute to the development of serotonin syndrome.

Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.