Clinical Neuropharmacology

Skip Navigation LinksHome > January/February 2009 - Volume 32 - Issue 1 > Fentanyl-Induced Bradykinesia and Rigidity After Deep Brain...
Clinical Neuropharmacology:
doi: 10.1097/WNF.0b013e31817e23e3
Case Reports

Fentanyl-Induced Bradykinesia and Rigidity After Deep Brain Stimulation in a Patient With Parkinson Disease

Zesiewicz, Theresa A. MD, FAAN*; Hauser, Robert A. MD, FAAN*; Freeman, Alan MD†; Sullivan, Kelly L. MSPH*; Miller, Amber M. MD*; Halim, Tariq MD*

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A 58-year-old man with advanced Parkinson disease underwent battery replacement for a deep brain stimulator and experienced severe bradykinesia and rigidity postoperatively for 36 hours. The patient was administered fentanyl as an anesthetic during the procedure and as an analgesic periodically during the day after surgery. The severe bradykinesia and rigidity persisted despite reactivation of the deep brain stimulator and immediate reinstitution of Parkinson disease medications, but resolved completely several hours after discontinuation of fentanyl.

© 2009 Lippincott Williams & Wilkins, Inc.


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