Skip Navigation LinksHome > January/February 2009 - Volume 32 - Issue 1 > Dopamine Dysregulation Syndrome and Levodopa-Induced Dyskine...
Clinical Neuropharmacology:
doi: 10.1097/WNF.0b013e3181634ea6
Review Article

Dopamine Dysregulation Syndrome and Levodopa-Induced Dyskinesias in Parkinson Disease: Common Consequences of Anomalous Forms of Neural Plasticity

Linazasoro, Gurutz MD

Collapse Box

Abstract

Four to 10% of patients with Parkinson disease and chronically treated with levodopa undergo an addictionlike behavioral disturbance named dopamine dysregulation syndrome (DDS). This article suggests that patients with Parkinson disease could be especially prone to develop DDS due to the dopamine deficiency and the "priming" of neural networks by the chronic use of drugs with a short half-life, such as levodopa. These suggestions are based on the clinical and molecular similarities between levodopa-induced dyskinesias and behavioral alterations seen in DDS and addiction to illegal drugs. Motor and behavioral abnormalities can be seen as the consequence of common mechanisms involving anomalous forms of neural plasticity. These forms affect parts of the cortical-basal ganglia-thalamocortical circuits that are topographically organized to differently modulate emotional and motor functions. Recent evidence using positron emission tomography provides support to this idea. By contrast, molecular data suggest that functional segregation may be lost in addiction, DDS, and dyskinesias. The existence of common pathogenic mechanisms for both phenomena could provide the basis for common therapeutic strategies.

© 2009 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.