Activity of Oxiracetam in Patients with Organic Brain Syndrome: A Neuropsychological Study.Moglia, A.; Sinforiani, E.; Zandrini, C.; Gualtieri, S.; Corsico, R.; Arrigo, A.Clinical Neuropharmacology: 1986 Article: PDF Only Abstract Summary: Oxiracetam is a new psychotropic drug that has been shown to positively affect processes both in animals and in patients with impaired brain function. The aim of this study was the evaluation of the effects of oxiracetam treatment on clinical symptoms in 43 patients with organic brain syndrome (OBS). After a 2-week washout period, patients were assigned to either oxiracetam or placebo, according to a randomized, double-blind, between-patients design. Both oxiracetam and placebo were orally given bid for 8 weeks; daily dose of oxiracetam was 2 +/- 800 mg. In OBS patients with a mild to moderate degree of cognitive impairment, oxiracetam showed to improve cognitive functions, logical performance, and attention. Other behavioral and functional parameters were also positively modified. (C) Williams & Wilkins 1986. All Rights Reserved.