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Corneal Confocal Microscopy Findings in Sporadic Cases of Pre-Descemet Corneal Dystrophy

Kontadakis, Georgios A. M.D., M.Sc.; Kymionis, George D. M.D., Ph.D.; Kankariya, Vardhaman P. M.D.; Papadiamantis, Anastasios G. M.Sc.; Pallikaris, Aristofanis I. M.Sc.

Eye & Contact Lens: Science & Clinical Practice:
doi: 10.1097/ICL.0b013e318273be9f
Case Report

Purpose: To present corneal confocal microscopy (CCM) findings in a series of patients with pre-Descemet corneal dystrophy (PDCD).

Methods: A 28-year-old man, a 50-year-old man, a 30-year-old woman, and a 31-year-old man were clinically diagnosed with PDCD on slit lamp microscopic evaluation. All patients were evaluated by means of CCM. The parents of the patients were clinically evaluated. Two of the patients underwent photorefractive keratectomy.

Results: In all the patients, CCM revealed highly reflective stromal particles and pleomorphic structures that included particles in the deep stroma, immediately anterior to the Descemet membrane extending up to 60 μm from endothelium. No evidence of PDCD was observed clinically in the parents of the patients. Postoperative course of photorefractive keratectomy was uneventful for both of the patients.

Conclusions: With the use of CCM, a specific pattern of findings seemed to be related with PDCD in this series of sporadic cases.

Author Information

Institute of Vision and Optics (G.A.K., G.D.K., V.P.K., A.G.P., A.I.P.), University of Crete, Crete, Greece; and Sai Surya Eye Care (V.P.K.), Maharashtra, India.

Address correspondence to Georgios A. Kontadakis, M.D., M.Sc., Institute of Vision and Optics (IVO), University of Crete, Medical School, 71003 Heraklion, Crete, Greece; e-mail:

Supported by Special Research Account of the University of Crete.

None of the authors has financial interest in any of the materials or methods discussed.

Accepted September 10, 2012

© 2014 Contact Lens Association of Ophthalmologists, Inc.