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Keratoconus in a Case of Lipoid Proteinosis

Acar, Ugur M.D.; Yildiz, Elvin H. M.D.; Yuksel, Dilek M.D.; Ustun, Huseyin M.D.; Unlu, Nurten M.D.

doi: 10.1097/ICL.0b013e3182657dc6
Case Report

Purpose: To report a patient of lipoid proteinosis (LP) with bilateral keratoconus.

Methods: A 16-year-old boy presented to our institution with a complaint of gradual decrease in vision over the past 4 years in both eyes and a contact lens intolerance. He had a hoarse voice and multiple areas of hyperpigmented lesions over the head and neck region. Slit lamp biomicroscopy of the both eyes showed multiple round solid pearly lesions along the upper and lower lid margins and a mild central corneal ectasia in both eyes. Central corneal thickness and the keratometric values were measured by using Scheimpflug imaging (Pentacam), and the results were compatible with keratoconus. The histopathologic examination of the lesions taken from bilateral eyelid margins showed hyalinosis, papillomatosis, and depositions of eosinophilic material around the blood vessels, which were compatible with LP.

Conclusions: With this report, we describe a case of LP with keratoconus. As seen in our case, LP and its characteristic eyelid margin lesions in keratoconus patients can be associated with a contact lens intolerance.

Department of Ophthalmology (U.A.), Ministry of Health, Semdinli State Hospital, Hakkari, Turkey; and Departments of Ophthalmology (E.H.Y., D.Y. and N.U.) and Pathology (H.U.), Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey.

Address for correspondence and reprint requests to Ugur Acar, M.D., Department of Ophthalmology, Ministry of Health, Semdinli State Hospital, Hakkari, Ankara, Turkey; e-mail: druguracar@gmail.com

The authors have no funding or conflicts of interest to disclose.

Accepted June 19, 2012

© 2013 Contact Lens Association of Ophthalmologists, Inc.