Eye & Contact Lens

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Eye & Contact Lens: Science & Clinical Practice:
doi: 10.1097/ICL.0b013e3181f91f2f

Severity and Determinants of Pinguecula in a Hospital-Based Population

Mimura, Tatsuya M.D.; Usui, Tomohiko M.D.; Obata, Hiroto M.D.; Yamagami, Satoru M.D.; Mori, Mikiro M.D.; Funatsu, Hideharu M.D.; Noma, Hidetaka M.D.; Dou, Kazuhiro M.D.; Amano, Shiro M.D.

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Objectives: Pinguecula is a relatively frequent disease; however, there have been no reports about the grade of pinguecula. We investigated the relationship between age and the prevalence and severity of pinguecula by using a grading system and compared the grade of pinguecula between men and women and between the nasal and temporal halves of the conjunctiva.

Methods: This was a prospective, randomized study of 1,040 patients aged 1 to 95 years, including 520 men and 520 age-matched women. The age, gender, medical history, ocular history, and grade of pingueculae located on the nasal and temporal conjunctiva were determined in all subjects.

Results: The prevalence of pinguecula increased dramatically with age. The mean grade was higher in male patients than in female patients for pingueculae located on both the nasal conjunctiva (P = 0.00072) and the temporal conjunctiva (P = 0.00035). However, there was no significant difference in the grade of pinguecula between the nasal and temporal conjunctiva.

Conclusions: This was the first assessment of the grade of pinguecula in a large series of patients. Our findings strongly suggest that pinguecula is an age-dependent lesion that occurs from young adulthood onward. The present grading system should also be useful for future clinical studies of pinguecula.

© 2011 Lippincott Williams & Wilkins, Inc.


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