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Omafilcon A (Proclear) Soft Contact Lenses in a Dry Eye Population

Lemp, Michael A. MD; Caffery, Barbara OD, FAAO; Lebow, Kenneth OD, FAAO; Lembach, Richard MD; Park, Juliana MD; Foulks, Gary MD; Hall, Brenda BSc, PhD; Bowers, Roderick PhD; McGarvey, Shirley BS, MBA; Young, Graeme BSc, MPhil, FCOptom, DCLP, FAAO
Eye & Contact Lens: January 1999
CONTACT LENSES: PDF Only

Purpose

We conducted a 3-month, randomized, comparative cross-over study to evaluate the clinical performance of lenses manufactured from omafilcon A on subjects with signs and symptoms of dry eye. The subjects' own daily wear soft lenses were used as controls.

Methods

Seventy-six subjects with objective evidence of dry eye, as defined in the NEI/Industry Workshop Report 1995, were fit with either the omafilcon A lenses (Proclear) or new control lenses. Subjects wore the lenses for 6 weeks and then crossed over to bilateral wear of the other lenses for an additional 6 weeks. During each part of the study, we examined subjects at 1 week, 1 month, and 6 weeks. Signs and symptoms of dry eye were evaluated, and on-eye dehydration of the lens was assessed.

Results

When the subjects were wearing the omafilcon A lenses, there was a statistically significant improvement in a number of subjective parameters including comfort, dryness, frequency of eye irritation, and frequency of burning. We found significantly less on-eye dehydration of the lens and fluorescein corneal staining with the omafilcon A lenses.

Conclusions

This study indicated that the daily wear of omafilcon A lenses provided better comfort, fewer symptoms, less on-eye dehydration, and less fluorescein corneal staining than other soft daily wear contact lenses in subjects with mild to moderate dry eye.

© 1999 The Contact Lens Association of Ophthalmologists, Inc.