New Treatments for Concussion: The Next Millennium BeckonsMcCrory, Paul MBBS, PhDClinical Journal of Sport Medicine: July 2001 - Volume 11 - Issue 3 - pp 190-193 Thematic Articles Abstract Author Information As increased understanding of the pathophysiology of mild traumatic brain injury and concussion develops, so the scientific rationale for interventional pharmacological therapy becomes paramount. A number of agents have been postulated or have been the subject of anecdotal noncontrolled trials. This paper reviews the published evidence in this regard. To date no effective pharmacological therapy exists that satisfies Class 1 evidence-based medicine criteria. Centre for Sports Medicine Research & Education, and Brain Research Institute, University of Melbourne, Melbourne, Australia Address correspondence to Paul McCrory, MBBS, PhD, 31 Grosvenor Parade, Balwyn, Victoria 3103, Australia. E-mail: pmccrory@ compuserve.com © 2001 Lippincott Williams & Wilkins, Inc.