Usability evaluations are necessary to determine the feasibility of nurses’ interactions with computerized clinical decision-support systems. Limitations and challenges of operations that inhibit or facilitate utilization in clinical practice can be identified. This study provided nurses with mobile information terminals, PDAs and tablet PCs, to improve point-of-care access to information. The purpose of this study was to determine usability issues associated with point-of-care technology. Eleven nurses were self-selected. Nurses were videotaped and audiotaped completing four tasks, including setting up the device and three resource search exercises. A research team member completed a usability checklist. Completion times for each task, success rate, and challenges experienced were documented. Four participants completed all tasks, with an average time of 3 minutes 22 seconds. Three participants were unable to complete any of the three tasks. Navigating within resources caused the greatest occurrence of deviations with 39 issues among all participants. Results of the usability evaluation suggest that nurses require a device that (1) is manageable to navigate and (2) utilizes a user-friendly interface, such as a one-time log-in system. Usability testing can be helpful to organizations as they document issues to be cognizant of during the implementation process, increasing the potential for successful implementation and sustained usability.