Critical Care Medicine

Skip Navigation LinksHome > September 2014 - Volume 42 - Issue 9 > Substance P Mediates Reduced Pneumonia Rates After Traumatic...
Critical Care Medicine:
doi: 10.1097/CCM.0000000000000486
Neurologic Critical Care

Substance P Mediates Reduced Pneumonia Rates After Traumatic Brain Injury

Yang, Sung MD; Stepien, David PhD; Hanseman, Dennis PhD; Robinson, Bryce MD; Goodman, Michael D. MD; Pritts, Timothy A. MD, PhD; Caldwell, Charles C. PhD; Remick, Daniel G. MD; Lentsch, Alex B. PhD

Supplemental Author Material
Collapse Box


Objectives: Traumatic brain injury results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia. However, whether traumatic brain injury directly impacts the host response to pneumonia is unknown. The objective of this study was to determine the nature of the relationship between traumatic brain injury and the prevalence of pneumonia in trauma patients and investigate the mechanism of this relationship using a murine model of traumatic brain injury with pneumonia.

Design: Data from the National Trauma Data Bank and a murine model of traumatic brain injury with postinjury pneumonia.

Setting: Academic medical centers in Cincinnati, OH, and Boston, MA.

Patients/Subjects: Trauma patients in the National Trauma Data Bank with a hospital length of stay greater than 2 days, age of at least 18 years at admission, and a blunt mechanism of injury. Subjects were female ICR mice 8–10 weeks old.

Interventions: Administration of a substance P receptor antagonist in mice.

Measurements and Main Results: Pneumonia rates were measured in trauma patients before and after risk adjustment using propensity scoring. In addition, survival and pulmonary inflammation were measured in mice undergoing traumatic brain injury with or without pneumonia. After risk adjustment, we found that traumatic brain injury patients had significantly lower rates of pneumonia compared to blunt trauma patients without traumatic brain injury. A murine model of traumatic brain injury reproduced these clinical findings with mice subjected to traumatic brain injury demonstrating increased bacterial clearance and survival after induction of pneumonia. To determine the mechanisms responsible for this improvement, the substance P receptor was blocked in mice after traumatic brain injury. This treatment abrogated the traumatic brain injury–associated increases in bacterial clearance and survival.

Conclusions: The data demonstrate that patients with traumatic brain injury have lower rates of pneumonia compared to non–head-injured trauma patients and suggest that the mechanism of this effect occurs through traumatic brain injury–induced release of substance P, which improves innate immunity to decrease pneumonia.

Copyright © by 2014 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.