Critical Care Medicine

Skip Navigation LinksHome > July 2014 - Volume 42 - Issue 7 > Chlorhexidine-Impregnated Dressing for Prevention of Cathete...
Critical Care Medicine:
doi: 10.1097/CCM.0000000000000319
Review Article

Chlorhexidine-Impregnated Dressing for Prevention of Catheter-Related Bloodstream Infection: A Meta-Analysis*

Safdar, Nasia MD, PhD1,2; O’Horo, John C. MD3; Ghufran, Aiman MD2; Bearden, Allison MD, MPH2; Didier, Maria Eugenia MD2; Chateau, Dan PhD4; Maki, Dennis G. MD2

Supplemental Author Material
Collapse Box


Objective: To assess the efficacy of a chlorhexidine-impregnated dressing for prevention of central venous catheter–related colonization and catheter-related bloodstream infection using meta-analysis.

Data Sources: Multiple computerized database searches supplemented by manual searches including relevant conference proceedings.

Study Selection: Randomized controlled trials evaluating the efficacy of a chlorhexidine-impregnated dressing compared with conventional dressings for prevention of catheter colonization and catheter-related bloodstream infection.

Data Extraction: Data were extracted on patient and catheter characteristics and outcomes.

Data Synthesis: Nine randomized controlled trials met the inclusion criteria. Use of a chlorhexidine-impregnated dressing resulted in a reduced prevalence of catheter-related bloodstream infection (random effects relative risk, 0.60; 95% CI, 0.41–0.88, p = 0.009). The prevalence of catheter colonization was also markedly reduced in the chlorhexidine-impregnated dressing group (random effects relative risk, 0.52; 95% CI, 0.43–0.64; p < 0.001). There was significant benefit for prevention of catheter colonization and catheter-related bloodstream infection, including arterial catheters used for hemodynamic monitoring. Other than in low birth weight infants, adverse effects were rare and minor.

Conclusions: Our analysis shows that a chlorhexidine-impregnated dressing is beneficial in preventing catheter colonization and, more importantly, catheter-related bloodstream infection and warrants routine use in patients at high risk of catheter-related bloodstream infection and central venous catheter or arterial catheter colonization.

© 2014 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins

Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.