Institutional members access full text with Ovid®

A Feasibility Study of Cerebral Oximetry During In-Hospital Mechanical and Manual Cardiopulmonary Resuscitation*

Parnia, Sam MD, PhD; Nasir, Asad MD; Ahn, Anna MD; Malik, Hanan MD; Yang, Jie PhD; Zhu, Jiawen MS; Dorazi, Francis DO; Richman, Paul MD

doi: 10.1097/CCM.0000000000000047
Neurologic Critical Care

Objective: A major hurdle limiting the ability to improve the quality of resuscitation has been the lack of a noninvasive real-time detection system capable of monitoring the quality of cerebral and other organ perfusion, as well as oxygen delivery during cardiopulmonary resuscitation. Here, we report on a novel system of cerebral perfusion targeted resuscitation.

Design: An observational study evaluating the role of cerebral oximetry (Equanox; Nonin, Plymouth, MI, and Invos; Covidien, Mansfield, MA) as a real-time marker of cerebral perfusion and oxygen delivery together with the impact of an automated mechanical chest compression system (Life Stat; Michigan Instruments, Grand Rapids, MI) on oxygen delivery and return of spontaneous circulation following in-hospital cardiac arrest.

Setting: Tertiary medical center.

Patients: In-hospital cardiac arrest patients (n = 34).

Main Results: Cerebral oximetry provided real-time information regarding the quality of perfusion and oxygen delivery. The use of automated mechanical chest compression device (n = 12) was associated with higher regional cerebral oxygen saturation compared with manual chest compression device (n = 22) (53.1% ± 23.4% vs 24% ± 25%, p = 0.002). There was a significant difference in mean regional cerebral oxygen saturation (median % ± interquartile range) in patients who achieved return of spontaneous circulation (n = 15) compared with those without return of spontaneous circulation (n = 19) (47.4% ± 21.4% vs 23% ± 18.42%, p < 0.001). After controlling for patients achieving return of spontaneous circulation or not, significantly higher mean regional cerebral oxygen saturation levels during cardiopulmonary resuscitation were observed in patients who were resuscitated using automated mechanical chest compression device (p < 0.001).

Conclusions: The integration of cerebral oximetry into cardiac arrest resuscitation provides a novel noninvasive method to determine the quality of cerebral perfusion and oxygen delivery to the brain. The use of automated mechanical chest compression device during in-hospital cardiac arrest may lead to improved oxygen delivery and organ perfusion.

* See also p. 1001.

All authors: Resuscitation Research Group, Division of Pulmonary & Critical Care, Department of Medicine, State University of New York at Stony Brook, Stony Brook Medical Center, T17-040 Health Sciences Center, Stony Brook, NY.

Supported, in part, by Stony Brook Medical Center, Department of Medicine Pilot Project Program Award.

The authors have disclosed that they do not have any potential conflicts of interest.

Address requests for reprints to: Sam Parnia, MD, PhD, MRCP, State University of New York at Stony Brook, Stony Brook Medical Center, T17-040 Health Sciences Center, Stony Brook, NY 11794–8172. E-mail: sam.parnia@stonybrookmedicine.edu

© 2014 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins