Critical Care Medicine

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Critical Care Medicine:
doi: 10.1097/CCM.0b013e31829a6eb4
Concise Definitive Review

In Silico Modeling: Methods and Applications to Trauma and Sepsis

Vodovotz, Yoram PhD1,2; Billiar, Timothy R. MD1

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Objectives: To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.

Data Sources: PubMed search and review of relevant medical literature.

Summary: Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.

Conclusions: Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole-organism, and population levels has suggested a positive feedback cycle of inflammation → damage → inflammation that manifests via organ-specific inflammatory switching networks. This structure may manifest as multicompartment “tipping points” that drive multiple organ dysfunction. This process may be amenable to rational inflammation reprogramming.

© 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins

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