Home Current Issue Previous Issues Published Ahead-of-Print Podcasts For Authors Journal Info
Skip Navigation LinksHome > August 2011 - Volume 39 - Issue 8 > The intraoperative decrease of selenium is associated with t...
Critical Care Medicine:
doi: 10.1097/CCM.0b013e3182190d48
Clinical Investigations

The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients*

Stoppe, Christian MD; Schälte, Gereon MD; Rossaint, Rolf MD, PhD; Coburn, Mark MD, PhD; Graf, Beatrix MD; Spillner, Jan MD; Marx, Gernot MD, PhD; Rex, Steffen MD, PhD

Collapse Box


Objective: The trace elements selenium, copper, and zinc are essential for maintaining the oxidative balance. A depletion of antioxidative trace elements has been observed in critically ill patients and is associated with the development of multiorgan dysfunction and an increased mortality. Cardiac surgery using cardiopulmonary bypass provokes ischemia-reperfusion-mediated oxidative stress. We hypothesized that an intraoperative decrease of circulating trace elements may be involved in this response.

Design: Prospective observational clinical study.

Setting: University hospital cardiothoracic operation theater and intensive care unit.

Patients: Sixty patients (age 65 ± 14 yrs) undergoing cardiac surgery with the use of cardiopulmonary bypass.

Measurements and Main Results: Whole blood concentrations of selenium, copper, and zinc were measured after induction of anesthesia and 1 hr after admission to the intensive care unit. All patients were separated in a priori defined subgroups according to the development of no organ failure, single organ failure, and ≥2 organ failures in the postoperative period.

Results: Fifty patients exhibited a significant selenium deficiency already before surgery, whereas copper and zinc concentrations were within the reference range.

In all patients, blood levels of selenium, copper, and zinc were significantly reduced after end of surgery when compared to preoperative values (selenium: 89.05 ± 12.65 to 70.84 ± 10.46 μg/L; zinc: 5.15 ± 0.68 to 4.19 ± 0.73 mg/L; copper: 0.86 ± 0.15 to 0.65 ± 0.14 mg/L; p < .001).

During their intensive care unit stay, 17 patients were free from any organ failure, while 31 patients developed single-organ failure and 12 patients multiple organ failure.

Multilogistic regression analysis showed that selenium concentrations at end of surgery were independently associated with the postoperative occurrence of multiorgan failure (p = .0026, odds ratio 0.8479, 95% confidence interval 0.7617 to 0.9440).

Conclusions: Cardiac surgery using cardiopulmonary bypass resulted in a profound intraoperative decrease of whole blood levels of antioxidant trace elements. Low selenium concentrations at end of surgery were an independent predictor for the postoperative development of multiorgan failure.

© 2011 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins

Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.