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Is the evolving management of intra-abdominal hypertension and abdominal compartment syndrome improving survival?*

Cheatham, Michael L. MD, FCCM; Safcsak, Karen RN

doi: 10.1097/CCM.0b013e3181b9e9b1
Continuing Medical Education Articles

Objective: The diagnosis and management of intra-abdominal hypertension and abdominal compartment syndrome have changed significantly over the past decade with improved understanding of the pathophysiology and appropriate treatment of these disease processes. Serial intra-abdominal pressure measurements, nonoperative pressure-reducing interventions, and early abdominal decompression for refractory intra-abdominal hypertension or abdominal compartment syndrome are all key elements of this evolving strategy.

Design: Prospective, observational study.

Setting: Tertiary referral/level I trauma center.

Patients: Four hundred seventy-eight consecutive patients requiring an open abdomen for the management of intra-abdominal hypertension or abdominal compartment syndrome.

Interventions: Patients were managed by a defined group of surgical intensivists using established definitions and an evidence-based management algorithm. Both univariate and multivariate analyses were performed to identify patient and management factors associated with improved survival.

Measurements and Main Results: Whereas patient demographics and severity of illness remained unchanged over the 6-yr study period, the use of a continually revised intra-abdominal hypertension/abdominal compartment syndrome management algorithm significantly increased patient survival to hospital discharge from 50% to 72% (p = .015). Clinically significant decreases in resource utilization and an increase in same-admission primary fascial closure from 59% to 81% were recognized. Development of abdominal compartment syndrome, prophylactic use of an open abdomen to prevent development of intra-abdominal hypertension/abdominal compartment syndrome, and use of a multi-modality surgical/medical management algorithm were identified as independent predictors of survival.

Conclusions: A comprehensive evidence-based management strategy that includes early use of an open abdomen in patients at risk significantly improves survival from intra-abdominal hypertension/abdominal compartment syndrome. This improvement is not achieved at the cost of increased resource utilization and is associated with an increased rate of primary fascial closure.

Director (MLC), Surgical/Trauma Intensive Care Units, Orlando Regional Medical Center, Orlando, FL; and Project Manager (KS), Surgical Critical Care Research, Orlando Regional Medical Center, Orlando, FL.

For information regarding this article, E-mail: michael.cheatham@orlandohealth.com

© 2010 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins