Critical Care Medicine

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Critical Care Medicine:
doi: 10.1097/CCM.0b013e3181bc81ec
Clinical Investigations

Central venous saturation is a predictor of reintubation in difficult-to-wean patients*

Teixeira, Cassiano MD; da Silva, Nilton Brandão PhD; Savi, Augusto RPT; Vieira, Silvia Regina Rios PhD; Nasi, Luis Antônio MD; Friedman, Gilberto PhD; Oliveira, Roselaine Pinheiro MD; Cremonese, Ricardo Viegas MD; Tonietto, Túlio Frederico MD; Bressel, Mathias Azevedo Bastian MSc; Maccari, Juçara Gasparetto MD; Wickert, Ricardo RPT; Borges, Luis Guilherme RPT

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Objective: To evaluate the predictive value of central venous saturation to detect extubation failure in difficult-to-wean patients.

Design: Cohort, multicentric, clinical study.

Setting: Three medical-surgical intensive care units.

Patients: All difficult-to-wean patients (defined as failure to tolerate the first 2-hr T-tube trial), mechanically ventilated for >48 hrs, were extubated after undergoing a two-step weaning protocol (measurements of predictors followed by a T-tube trial). Extubation failure was defined as the need of reintubation within 48 hrs.

Interventions: The weaning protocol evaluated hemodynamic and ventilation parameters, and arterial and venous gases during mechanical ventilation (immediately before T-tube trial), and at the 30th min of spontaneous breathing trial.

Measurements and Main Results: Seventy-three patients were enrolled in the study over a 6-mo period. Reintubation rate was 42.5%. Analysis by logistic regression revealed that central venous saturation was the only variable able to discriminate outcome of extubation. Reduction of central venous saturation by >4.5% was an independent predictor of reintubation, with odds ratio of 49.4 (95% confidence interval 12.1–201.5), a sensitivity of 88%, and a specificity of 95%. Reduction of central venous saturation during spontaneous breathing trial was associated with extubation failure and could reflect the increase of respiratory muscles oxygen consumption.

Conclusions: Central venous saturation was an early and independent predictor of extubation failure and may be a valuable accurate parameter to be included in weaning protocols of difficult-to-wean patients.

© 2010 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins

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