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Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients*

Weber-Carstens, Steffen MD; Koch, Susanne MD; Spuler, Simone PhD; Spies, Claudia D. PhD; Bubser, Florian MD; Wernecke, Klaus D. PhD; Deja, Maria MD

Critical Care Medicine:
doi: 10.1097/CCM.0b013e3181a92f28
Neurologic Critical Care
Abstract

Objectives: To investigate the predictive value of electrophysiological measurements including validation of muscle membrane excitability on the development of intensive care unit (ICU)-aquired paresis.

Design: Prospective observational study.

Setting: University ICU.

Patients: Surgical ICU patients selected upon a simplified acute physiology score ≥20 on three successive days within 1 wk after ICU admission.

Interventions: We performed serial electrophysiological measurements with onset of critical illness including conventional electrophysiological parameters and compound muscle action potentials after direct muscle stimulation (dmCMAP). Patients’ awareness and muscle strength were measured sequentially by Ramsay sedation scale and an additional questionnaire and by Medical Research Council score, respectively.

Measurements and Main Results: Among 56 sedated patients 34 patients revealed reduced dmCMAP values <3 mV indicating a myopathic process within 7.5 (5 of 11) days after admission to the ICU. Abnormal dmCMAP anticipated ICU-acquired paresis upon emergence from sedation with a sensitivity and specificity of 83.3% and 88.8%, respectively (positive predictive value of 0.91). Multivariate logistic regression analyses revealed that validating dmCMAP during early course of critical illness had significant diagnostic utility to anticipate ICU-acquired paresis (p = .004; odds ratio = .47; 95% confidence interval = .28–.79).

Conclusions: Abnormal dmCMAP occurred within the first week after admission to the ICU and pointed towards a myopathic process as the primary cause of ICU-acquired paresis. Validation of dmCMAP with onset of critical illness allows an early prediction of ICU-acquired paresis and adds important information to clinical estimation of the patients’ motor function.

Author Information

From the Department of Anesthesiology and Intensive Care Medicine (SW-C, SK, CDS, FB, MD), Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany; Muscle Research Unit (SS), Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical Biometry (K-DW), Charité-Universitätsmedizin Berlin, Berlin, Germany.

This study was supported, in part, by Grant KFO 192, WE 4386/1-1 from the Deutsche Forschungsgemeinschaft.

The authors have not disclosed any potential conflicts of interest.

For information regarding this article, E-mail: steffen.weber-carstens@charite.de

© 2009 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins