Coma is a medical emergency and may constitute a diagnostic and therapeutic challenge for the intensivist.
To review currently available data on the etiology, diagnosis, and outcome of coma. To propose an evidence-based approach for the clinical management of the comatose patient.
Search of Medline and Cochrane databases; manual review of bibliographies from selected articles and monographs.
Coma and other states of impaired consciousness are signs of extensive dysfunction or injury involving the brainstem, diencephalon, or cerebral cortex and are associated with a substantial risk of death and disability. Management of impaired consciousness includes prompt stabilization of vital physiologic functions to prevent secondary neurologic injury, etiological diagnosis, and the institution of brain-directed therapeutic or preventive measures. Neurologic prognosis is determined by the underlying etiology and may be predicted by the combination of clinical signs and electrophysiological tests.
On completion of this article, the reader should be able to:
Dr. Stevens has disclosed that he is the recipient of direct grant/research funds from the National Institutes of Health, Public Health Service; Dr. Bhardwaj has disclosed that he was the recipient of direct grant/research funds from the American Heart Association and that he is/was the recipient of grant/research funds from the National Institutes of Health, Public Health Service.
Wolters Kluwer Health has identified and resolved all faculty conflicts of interests regarding this educational activity.
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Assistant Professor, Division of Neurosciences Critical Care, Department of Anesthesiology/Critical Care Medicine, Neurology and Neurosurgery (RDS), Vice Chairman, Department of Neurology, Co-Director, Division of Neurosciences Critical Care, Associate Professor of Neurology, Neurological Surgery, Anesthesiology/Critical Care Medicine (AB), The Johns Hopkins University School of Medicine, Baltimore, MD.
Supported, in part, by grant NS 046379 from the U.S. Public Health Service National Institutes of Health.