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Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of a randomized phase II trial

Dellinger, R. Phillip MD, FCCM; Zimmerman, Janice L. MD, FCCM; Taylor, Robert W. MD, FCCM; Straube, Richard C. MD; Hauser, David L. PhD; Criner, Gerard J. MD; Davis, Kenneth Jr, MD; Hyers, Thomas M. MD; Papadakos, Peter MD, FCCM

Feature Article

Objectives To evaluate the safety and physiologic response of inhaled nitric oxide (NO) in patients with acute respiratory distress syndrome (ARDS). In addition, the effect of various doses of inhaled NO on clinical outcome parameters was assessed.

Design Prospective, multicenter, randomized, double-blind, placebo-controlled study.

Setting Intensive care units of 30 academic, teaching, and community hospitals in the United States.

Patients Patients with ARDS, as defined by the American-European Consensus Conference, were enrolled into the study if the onset of disease was within 72 hrs of randomization.

Interventions Patients were randomized to receive placebo (nitrogen gas) or inhaled NO at concentrations of 1.25, 5, 20, 40, or 80 ppm.

Measurements and Main Results Acute Increases in PaO2, decreases in mean pulmonary arterial pressure, Intensity of mechanical ventilation, and oxygenation index were examined. Clinical outcomes examined were the dose effects of inhaled NO on mortality, the number of days alive and off mechanical ventilation, and the number of days alive after meeting oxygenation criteria for extubation.

A total of 177 patients were enrolled over a 14-month period. An acute response to treatment gas, defined as a PaO2 Increase >or=to20%, was seen in 60% of the patients receiving inhaled NO with no significant differences between dose groups. Twenty-four percent of placebo patients also had an acute response to treatment gas during the first 4 hrs. The initial increase in oxygenation translated into a reduction in the FIO2 over the first day and in the intensity of mechanical ventilation over the first 4 days of treatment, as measured by the oxygenation index. There were no differences among the pooled inhaled NO groups and placebo with respect to mortality rate, the number of days alive and off mechanical ventilation, or the number of days alive after meeting oxygenation criteria for extubation. However, patients receiving 5 ppm inhaled NO showed an improvement in these parameters. In this dose group, the percentage of patients alive and off mechanical ventilation at day 28 (a post hoc analysis) was higher (62% vs. 44%) than the placebo group.

There was no apparent difference in the number or type of adverse events reported among those patients receiving inhaled NO compared with placebo.Four patients had methemoglobin concentrations >5%. The mean inspired nitrogen dioxide concentration in inhaled NO patients was 1.5 ppm.

Conclusions From this placebo-controlled study, inhaled NO appears to be well tolerated in the population of ARDS patients studied. With mechanical ventilation held constant, inhaled NO is associated with a significant improvement in oxygenation compared with placebo over the first 4 hrs of treatment. An improvement in oxygenation index was observed over the first 4 days. Larger phase III studies are needed to ascertain if these acute physiologic improvements can lead to altered clinical outcome. (Crit Care Med 1998; 26:15-23)

The Inhaled Nitric Oxide in ARDS Study Group.

From the University of Missouri, Columbia, MO (Dr. Dellinger); Baylor College of Medicine, Houston, TX (Dr. Zimmerman); St. John's Mercy Medical Center, St. Louis, MO (Dr. Taylor); Ohmeda, Pharmaceutical Products Division, Liberty Corner, NJ (Drs. Straube and Hauser); Temple University School of Medicine, Philadelphia, PA (Dr. Criner); University of Cincinnati, Cincinnati, OH (Dr. Davis); St. Louis University, St. Louis, MO (Dr. Hyers); and Rochester University, Rochester, MN (Dr. Papadakos).

Supported, in part, by Ohmeda, Pharmaceutical Products Division, Liberty Corner, NJ.

© Williams & Wilkins 1998. All Rights Reserved.