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Effect of Micronized Fenofibrate and Losartan Combination on Uric Acid Metabolism in Hypertensive Patients with Hyperuricemia

Elisaf, M.; Tsimichodimos, V.; Bairaktari, E.*; Siamopoulos, K. C.

Journal of Cardiovascular Pharmacology: July 1999 - Volume 34 - Issue 1 - p 60-63

It has been reported that micronized fenofibrate and losartan can significantly decrease serum uric acid levels by augmenting uric acid excretion. We undertook this study to evaluate the effects of the combination treatment with micronized fenofibrate and losartan in nondiabetic hypertensive dyslipidemic patients with hyperuricemia (serum uric acid, >7 mg/dl). A total of 25 patients (15 men, 10 women) aged 21-66 years was studied. In all patients, serum lipid parameters, including Lp(a), fibrinogen, and uric acid levels, as well as fractional excretion of uric acid (FEUA) were obtained before treatment, 8 weeks after micronized fenofibrate treatment (200 mg daily), and 8 weeks after combination therapy with micronized fenofibrate (200 mg daily) and losartan (50 mg daily). Fenofibrate alone significantly decreased total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, Apo B, Lp(a), fibrinogen, and uric acid levels (from 7.6 ± 0.55 to 5.6 ± 0.5 mg/dl; p < 0.0001) and increased high-density lipoprotein (HDL) cholesterol, Apo A1, and FEUA (from 6.5 ± 1.8% to 12.2 ± 4%; p < 0.0001). The addition of losartan beyond the decrease in blood pressure values did not significantly alter serum metabolic parameters. However, a small additional decrease in serum uric acid levels (from 5.6 ± 0.5 to 4.9 ± 1 mg/dl; p < 0.05) was found because of a further increase in FEUA (from 12.2 ± 4% to 14 ± 5.5%; p < 0.05). It is concluded that the combination of micronized fenofibrate and losartan is useful for the management of patients with multiple metabolic abnormalities, including hyperuricemia.

Department of Internal Medicine and *Biochemistry Laboratory, Medical School, University of Ioannina, Ioannina, Greece

Received November 2, 1998; revision accepted February 18, 1999.

Address correspondence and reprint requests to Dr. M. Elisaf at Department of Internal Medicine, Medical School, University of Ioannina, 451 10 Ioannina, Greece.

© 1999 Lippincott Williams & Wilkins, Inc.