Abstract: The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.
*MedStar Cardiovascular Research Network, MedStar Heart Institute, Medstar Washington Hospital Center, Washington, DC; and
†Departamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
Reprints: Michael J. Lipinski, MD, PhD, MedStar Cardiovascular Research Network, MedStar Heart Institute, MedStar Washington Hospital Center, 110 Irving St, NW, Suite 4B-1, Washington, DC 20010 (e-mail: email@example.com).
The authors report no conflicts of interest.
Received December 12, 2013
Accepted December 14, 2013