Molecule 16673-34-0: A New Tool in Our Arsenal Against Inflammation

Lipinski, Michael J. MD, PhD*; Frias, Juan C. PhD

Journal of Cardiovascular Pharmacology:
doi: 10.1097/FJC.0000000000000070
Commentary
Abstract

Abstract: The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.

Author Information

*MedStar Cardiovascular Research Network, MedStar Heart Institute, Medstar Washington Hospital Center, Washington, DC; and

Departamento Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.

Reprints: Michael J. Lipinski, MD, PhD, MedStar Cardiovascular Research Network, MedStar Heart Institute, MedStar Washington Hospital Center, 110 Irving St, NW, Suite 4B-1, Washington, DC 20010 (e-mail: mjlipinski12@gmail.com).

The authors report no conflicts of interest.

Received December 12, 2013

Accepted December 14, 2013

© 2014 by Lippincott Williams & Wilkins.