Skip Navigation LinksHome > August 2012 - Volume 60 - Issue 2 > Different Roles of PPAR-γ Activity on Physiological and Path...
Journal of Cardiovascular Pharmacology:
doi: 10.1097/FJC.0b013e3182592d7b
Original Article

Different Roles of PPAR-γ Activity on Physiological and Pathological Alteration After Myocardial Ischemia

Nagashima, Ayako MD*; Watanabe, Ryo BS*; Ogawa, Masahito MS; Suzuki, Jun-ichi MD, PhD; Masumura, Mayumi MD*; Hishikari, Keiichi MD*; Shimizu, Tomoko PhD; Takayama, Kiyoshi PhD; Hirata, Yasunobu MD, PhD; Nagai, Ryozo MD, PhD§; Isobe, Mitsuaki MD, PhD*

Collapse Box

Abstract

Background: Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor-γ (PPAR-γ). Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated.

Methods and Results: The left anterior descending arteries were ligated to induce myocardial infarction in rats. The animals were assigned to 4 groups: (1) control (saline, n = 6), (2) telmisartan (10 mg·kg−1·d−1, n = 6), (3) telmisartan + GW9662 (PPAR-γ-antagonist) (10 mg·kg−1·d−1 of telmisartan and 1 mg·kg−1·d−1 of GW9662, n = 6), and (4) amlodipine (10 mg·kg−1·d−1, n = 8) groups. Telmisartan reduced mean blood pressure compared with that in the control group. There was no statistical difference among the telmisartan, telmisartan + GW9662 and amlodipine groups. The end-diastolic left ventricular diameter was smaller in telmisartan group compared with that in the control group; GW9662 negated the effect of telmisartan. The thickness of the ventricular septum was kept in the telmisartan group compared with that in the control group; GW9662 negated the effect. Histopathologic analyses showed that telmisartan suppressed myocardial fibrosis compared with that of the control, whereas GW9662 negated the telmisartan effect.

Conclusions: Telmisartan suppresses pathological remodeling by PPAR-γ agonistic activities independent of its antihypertensive effects.

© 2012 Lippincott Williams & Wilkins, Inc.

Follow Us!

Login

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.