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Efficacy of Grape Seed Proanthocyanidins on Cardioprotection During Isoproterenol-induced Myocardial Injury in Rats

Karthikeyan, K PhD*; Bai, B R Sarala PhD; Devaraj, S Niranjali PhD*

Journal of Cardiovascular Pharmacology:
doi: 10.1097/FJC.0b013e3181970c01
Original Article
Abstract

The present study was done to evaluate the role of grape seed proanthocyanidins (GSPs) in isoproterenol (ISO)-induced myocardial injury in rats. Male albino Wistar rats were pretreated with GSP (50, 100, and 150 mg/kg), 6 days a week, for 5 weeks. Induction of rats with ISO (85 mg/kg body weight, intraperitoneally) for 2 days resulted in a significant elevation of thiobarbituric acid-reactive substances in serum, mitochondrial cholesterol, triglycerides, and free fatty acids. A significant decrease was observed in serum reduced glutathione; ascorbic acid; α-tocopherol; ceruloplasmin; and mitochondrial cytochromes (b, c, c1, and aa3), phospholipids, and adenosine triphosphate. Pretreatment with GSP (100 and 150 mg/kg) positively altered the levels of all the parameters studied and restored normal mitochondrial function when compared with ISO-induced rats. The effect at a dose of 50 mg/kg was not promising when compared with the other 2 doses (100 and 150 mg/kg). These results confirm the efficacy of GSP in alleviating ISO-induced myocardial injury.

Author Information

From the Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.

The authors report no conflicts of interest.

Received for publication June 24, 2008; accepted November 17, 2008.

Reprints: Dr. K. Karthikeyan, PhD, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India (e-mail: karthik_research@yahoo.com) and Dr. S. Niranjali Devaraj, PhD, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India (e-mail: niranjali@yahoo.com).

© 2009 Lippincott Williams & Wilkins, Inc.