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Pharmacology and Safety of Tetradecylthioacetic Acid (TTA): Phase-1 Study

Pettersen, Reidar J MD*; Salem, Mohamed MD, PhD*; Skorve, Jon PhD†‡; Ulvik, Rune J MD, PhD†‡; Berge, Rolf K PhD†‡; Nordrehaug, Jan Erik MD, PhD*

Journal of Cardiovascular Pharmacology:
doi: 10.1097/FJC.0b013e3181673be0
Original Article

This study describes the clinical, hematological, and biochemical safety of tetradecylthioacetic acid (TTA). A total of 18 healthy volunteers were included. Subjects were randomly assigned into 3 groups according to the daily given dose of TTA: group 1 (200 mg), group 2 (600 mg), and group 3 (1000 mg). TTA was given as a single oral dose for 7 consecutive days. Safety was evaluated by following the adverse events, vital signs, and hematological and biochemical parameters in blood and urine samples. Efficacy was estimated through its effects on plasma lipids profile. Few adverse events of mild severity were reported. No clinically significant changes were observed in the hematological or clinical chemical parameters in blood/urine. TTA did not induce significant changes in the blood lipids or free fatty acids, but it did result in an increase in plasma concentration of Δ9 desaturated TTA (TTA: 1n-8). Serum concentration pattern of TTA at day 1 showed a 1.5-hour lag time followed by a rapid absorption and a slower elimination phase. The median peak values were 2.9 mg/L (range, 1.1 to 5.4 mg/L), 11.5 mg/L (range, 4 to 35 mg/L), and 11 mg/L (range, 5 to 25 mg/L), in groups 1, 2, and 3, respectively (P = 0.006). The time to peak levels were 3.5 hours (range, 2.5 to 6.5 hours), 2.5 hours (range, 2.5 to 4.5 hours), and 4.5 hours (range, 2.5 to 12 hours), respectively (P = 0.2). TTA is safe and well tolerated.

Author Information

From the *Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; †Institute of medicine, University of Bergen and ‡Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.

Received for publication December 17, 2007; accepted June 4, 2008.

The authors state that they have no financial interest in the products mentioned within this article.

Reprints: Reidar J. Pettersen, MD, Haukeland University Hospital, Department of Heart Disease N-5021 Bergen, Norway (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.