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Comparative Study of the Effects of Lacidipine and Enalapril on the Left Ventricular Cardiomyocyte Remodeling in Spontaneously Hypertensive Rats

Cagalinec, Michal* †; Kyselovic, Jan PhD; Blaskova, Eva PhD; Bacharova, Ljuba MD*; Chorvat, Dusan Jr PhD*; Chorvatova, Alzbeta PhD§ ¶

Journal of Cardiovascular Pharmacology:
doi: 10.1097/01.fjc.0000211728.23304.ad
Original Articles
Abstract

Antihypertensive medications are the most efficient drugs in achieving regression of myocardial hypertrophy in both clinical studies and animal models of hypertension. Nevertheless, there is a lack of clear and concise comparative study of their effects on the modulation of cardiomyocyte morphology and function. Here, we assessed the tissue-protective actions of 2 of these drugs, the calcium channel blocker lacidipine (3 mg/kg/day) and the angiotensin-converting enzyme-inhibitor enalapril (10 mg/kg/day) in vivo, after 8 weeks of treatment of 12-week-old spontaneously hypertensive rats, as well as in vitro, after short-term (4 min) application to isolated cardiomyocytes. Left ventricular hypertrophy (LVH) was compared at organ, tissue, and single-cell level. Our data showed that both drugs prevented the LVH of 20-week-old spontaneously hypertensive rats, but only lacidipine significantly decreased the cardiomyocyte size. Similarly, the single-cell contractility was significantly lowered in lacidipine-treated rats only. The effect of lacidipine was initiated shortly after exposure to the drug in a dose-dependent manner at 0.5 Hz, as well as at 2 Hz, with EC50 of 10−7 mol/L. These results can help in understanding the effects of these drugs on the prevention of LVH.

Author Information

*International Laser Centre, Bratislava, Slovakia

Faculty of Mathematics, Physics, and Informatics, Comenius University, Bratislava

Department of Pharmacology, Comenius University, Odbojarov 10, Bratislava

§Research Centre of Sainte-Justine Hospital, Montreal, Canada

Department of Pediatrics, University of Montreal, Montreal

This work was supported by Collaborative Linkage grant LST.CLG.979836 from NATO and partly by the grant 1/0507/03 from the Science Grant Agency VEGA, Slovakia. A.C. is a “Fonds de la Recherche en Santé du Québec” (No. 2948) fellow supported by the Canadian Institute for Health Research (MOP 74600).

Reprints: Dr. Chorvatova Alzbeta, Research Centre of Sainte-Justine Hospital, 3175 Côte Sainte Catherine, H3 T 1C5 Montreal, Canada (e-mail: alzbeta.chorvatova@recherche-ste-justine.qc.ca)

Received for publication October 24, 2005; accepted March 17, 2006

© 2006 Lippincott Williams & Wilkins, Inc.