Ginger Lowers Blood Pressure Through Blockade of Voltage-Dependent Calcium Channels

Ghayur, Muhammad Nabeel MPhil; Gilani, Anwarul Hassan PhD

Journal of Cardiovascular Pharmacology:
Original Article
Abstract

Ginger (Zingiber officinale Roscoe), a well-known spice plant, has been used traditionally in a wide variety of ailments including hypertension. We report here the cardiovascular effects of ginger under controlled experimental conditions. The crude extract of ginger (Zo.Cr) induced a dose-dependent (0.3-3 mg/kg) fall in the arterial blood pressure of anesthetized rats. In guinea pig paired atria, Zo.Cr exhibited a cardiodepressant activity on the rate and force of spontaneous contractions. In rabbit thoracic aorta preparation, Zo.Cr relaxed the phenylephrine-induced vascular contraction at a dose 10 times higher than that required against K+ (80 mM)-induced contraction. Ca2+ channel-blocking (CCB) activity was confirmed when Zo.Cr shifted the Ca2+ dose-response curves to the right similar to the effect of verapamil. It also inhibited the phenylephrine (1 μM) control peaks in normal-Ca2+ and Ca2+-free solution, indicating that it acts at both the membrane-bound and the intracellular Ca2+ channels. When tested in endothelium-intact rat aorta, it again relaxed the K+-induced contraction at a dose 14 times less than that required for relaxing the PE-induced contraction. The vasodilator effect of Zo.Cr was endothelium-independent because it was not blocked by L-NAME (0.1 mM) or atropine (1 μM) and also was reproduced in the endothelium-denuded preparations at the same dose range. These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels.

Author Information

From the Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan.

Received for publication June 18, 2004; accepted October 27, 2004.

Reprints: Dr. Anwarul Hassan Gilani, Professor of Pharmacology, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan (e-mail: anwar.gilani@aku.edu).

© 2005 Lippincott Williams & Wilkins, Inc.