Objective: Weight gain during the menopausal transition is common. Although studies have suggested that weight gain is more likely related to aging than menopause, there is a reduction in resting energy expenditure with surgical or natural menopause that is independent of age and changes in body composition. The underlying mechanisms could include a reduction in core body temperature.
Methods: Data were obtained from two related studies. Sample size was 23 men and 25 women (12 premenopausal, 13 postmenopausal). In the Clinical Research Unit, core temperature was measured every minute for 24 h using an ingested temperature sensor.
Results: The mean 24-h core body temperature was 0.25±0.06°C lower in postmenopausal than premenopausal women (P=0.001). The mean 24 h core temperature was 0.34±0.05°C lower in men than in premenopausal women (P<0.001).
Conclusion: Postmenopausal women, like men, had lower core body temperatures than premenopausal women. This may have implications for midlife weight gain.
aNorthwestern Comprehensive Center on Obesity
bDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago
cDepartment of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA
* Lisa M. Neff and Mindy E. Hoffmann contributed equally to the writing of this article.
This work was presented in part in abstract form at the Endocrine Society Annual Meeting, June 2014.
Correspondence to Lisa Neff, MD, MS, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 530-30, Chicago, IL 60611, USA Tel: +1 312 503 3267; fax: +1 312 926 8693; e-mail: firstname.lastname@example.org
Received January 4, 2016
Accepted March 29, 2016