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The metabolic actions of neurotensin secreted from the gut

Ratner, Cecilia; Hundahl, Cecilie; Holst, Birgitte

doi: 10.1097/XCE.0000000000000085
Review Articles

Neurotensin (NT) is a 13 amino acid peptide hormone primarily expressed in the brain and in the gastrointestinal (GI) tract. NT in the brain is generally considered an anorexigenic neuropeptide, but the potential metabolic actions of GI tract NT have not been investigated extensively. In the GI tract, NT is mainly found in so-called N cells, but is also coexpressed with a number of functionally related hormones including glucagon-like peptide-1 (GLP-1) and peptide YY. NT, GLP-1, and peptide YY can further be released together in response to a number of different physiological stimuli and can coact on some but not all target organs. In line with the recent focus on developing antiobesity agents targeting more than one signaling pathway, NT may be a candidate for such polytherapy drugs in combination with other gut hormones such as GLP-1.

aLaboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology

bSection for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

Correspondence to Cecilia Ratner, PhD, Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute Building 18.5, Blegdamsvej 3B, 2200 Copenhagen N, Denmark Tel: +45 2299 9320; e-mail:

Received June 7, 2016

Accepted June 23, 2016

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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