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Relevance of low testosterone to nonalcoholic fatty liver disease

Mody, Avnia,b,c; White, Donnac,d,e,f,g; Kanwal, Fasihad,e,f,g; Garcia, Jose M.b,c,g,h,i

doi: 10.1097/XCE.0000000000000057
Review articles

Nonalcoholic fatty liver disease (NAFLD) is a condition where there is excess accumulation of triglycerides in the liver in the absence of excess alcohol consumption. It ranges from simple steatosis to nonalcoholic steatohepatitis, which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, one of the most common causes of chronic liver disease in Western populations, is the hepatic component of the metabolic syndrome and is associated with increased visceral adipose tissue (VAT), insulin resistance, and dyslipidemia. Studies have also shown that testosterone deficiency is associated with increased VAT and insulin resistance in men, whereas hyperandrogenemia has been associated with increased risk of insulin resistance and VAT in women. Thus, the aims of this review are to discuss the available experimental and epidemiological data evaluating the association between testosterone and NAFLD, to discuss the potential clinical relevance of these data, and to identify gaps in the literature.

aTexas A&M Health Science Center College of Medicine

bDivision of Diabetes, Endocrinology and Metabolism, Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) and Baylor College of Medicine (BCM)

cCenter for Translational Research on Inflammatory Diseases (CTRID), MEDVAMC

dSection of Gastroenterology and Hepatology, MEDVAMC and BCM

eClinical Epidemiology and Comparative Effectiveness Program, Houston VA Health Services Research Center of Innovation (IQuESt), MEDVAMC

fTexas Medical Center Digestive Disease Center

gDan L. Duncan Cancer Center

hDepartment of Molecular and Cell Biology

iHuffington Center on Aging, BCM, Houston, Texas, USA

Correspondence to Jose M. Garcia, MD, PhD, Division of Endocrinology, Diabetes and Metabolism, Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Bldg 109, Rm 210, Houston, TX 77030, USA Tel: +1 713 794 7989; fax: +1 713 794 7771; e-mail:

Received April 21, 2015

Accepted June 24, 2015

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
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