Cardiovascular Endocrinology

Skip Navigation LinksHome > March 2014 - Volume 3 - Issue 1 > Natriuretic peptides in animal models of cardiovascular dise...
Cardiovascular Endocrinology:
doi: 10.1097/XCE.0000000000000025
Cardiovascular Biomarkers in Animal Models - A Bridge to Human Disease Edited by Jens Peter Goetze and Lisbeth Hoier Olsen: Reviews

Natriuretic peptides in animal models of cardiovascular disease

Burley, Dwaine S.; Bice, Justin S.; Baxter, Gary F.

Collapse Box


Natriuretic peptides play a major role in cardiovascular homeostasis, and much of our knowledge on this stems from animal studies looking into the genetic knockout or overexpression of natriuretic peptides or their biological target, the natriuretic peptide receptor. Genetic perturbation of the natriuretic peptide system in rodents causes systemic hypertension, cardiac fibrosis, left ventricular hypertrophy, and heart failure. Moreover, animal models of acute myocardial infarction and heart failure have demonstrated the therapeutic potential of exogenously administered natriuretic peptides in treating human acute coronary syndromes and heart failure. In this review, we hope to highlight the importance of animal models in helping us understand the biological function and consequence of the natriuretic peptide system in cardiovascular disease.

© 2014Wolters Kluwer Health Lippincott Williams Wilkins

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.