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Glucocorticoids completely reverse refractory diuretic resistance in a patient with decompensated heart failure and gross edema

Liu, Chao; Tian, Li; Liu, Kunshen

Cardiovascular Endocrinology:
doi: 10.1097/XCE.0000000000000013
Case report
Abstract

Diuretic resistance is not uncommon in severe congestive heart failure patients. In most cases, diuretic resistance can be overcome by intravenous administration of a high dose of loop diuretics. Here we report the use of glucocorticoids to reverse refractory diuretic resistance in a congestive heart failure patient who failed with intravenous administration of a high dose of furosemide (1000 mg/day). A 65-year-old man with a history of triple vessel disease and systolic ventricular dysfunction developed refractory diuretic resistance. The glucocorticoids slowly but dramatically reversed diuretic resistance. As a result, there was a dramatic improvement in his renal function. The maximum daily urine output was 8950 ml/day on day 8. The average daily output was 5636 ml/day. Finally, the patient lost 42 kg of his body weight. Potential mechanisms using glucocorticoids to revert diuretic resistance are also discussed.

Author Information

Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China

Correspondence to Chao Liu, MD, Heart Center, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang 050031, Hebei Province, China Tel: +86 311 8591 7032; fax: +86 311 8591 7290; e-mail: dr.liuchao@gmail.com

Received July 5, 2013

Accepted September 5, 2013

© 2013Wolters Kluwer Health Lippincott Williams Wilkins

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