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Cardiovascular Endocrinology:
doi: 10.1097/XCE.0b013e328357a94c
Review article

Hypertension and bradykinin: a dangerous affair?

Katsi, Vasilikia; Katsimichas, Themistoklisb; Pittaras, Andreasb; Grassos, Charalambosb; Katsimichas, Alexandrosa; Tousoulis, Dimitriosb; Stefanadis, Christodoulosb; Kallikazaros, Ioannisa

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Abstract

Hypertension is a disorder of the heart and vessels that affects almost a billion individuals worldwide and is considered the most important preventable factor for premature death. Overall, 95% of all cases are deemed as primary or essential hypertension, where no cause can be identified. Essential hypertension has a complex pathophysiology, involving derailment of endocrine and sympathetic mechanisms, still not completely understood. The kallikrein–kinin system comprises a collection of autacoid peptides such as bradykinin that exert multiple physiologic actions and are of strategic importance for the regulation of blood pressure. Scientific research suggests that its impairment contributes toward the development of hypertension and hypertension-induced end-organ damage.

© 2012Wolters Kluwer Health Lippincott Williams Wilkins

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