Robinson-White, Stephanie MD; Conroy, Brenna BS; Slavish, Kathleen H. BA; Rosenzweig, Margaret PhD, APN-BC, AOCNP
Patient navigators have become highly prevalent within cancer care. Cancer care navigation was originally conceived by Harold P. Freeman, MD, in response to disproportionate late-stage cancer presentation among African Americans attributed, in part, to an inability to access complex and often confusing existing cancer care services. In an effort to address those disparities and improve cancer care access, Freeman1 started the first patient navigator program in 1990 at Harlem Hospital and later expanded to the Breast Examination Center of Harlem and the Ralph Lauren Center for Cancer Care and Prevention. The goal of the navigation intervention was to "assist patients with abnormal findings or cancer in navigating and, at times, circumnavigating to the hospital and human services bureaucracies to accomplish the follow-up and diagnosis of an abnormal finding on cancer screening tests and the treatment of cancer."1 Freeman et al2,3 differentiated patient navigator programs from other services designed to reduce healthcare disparities by emphasizing the need for navigators to be members of the community they intend to serve and that they be familiar with healthcare to allow navigators to personally relate to their patient.
Since 1990, the role of the patient navigator in healthcare and specifically in cancer care has grown to incorporate many titles and functions.4,5 Initially, patient navigation was not meant to address psychological, social, and physical support systems that are mainly directed at improving the quality of life of patients with cancer. However, with the recognition of the interconnection of psychosocial issues with adherence to screening and cancer treatment,6-13 cancer care navigation has evolved to include outcomes encompassing not only screening and diagnostic and treatment adherence but quality-of-life outcomes as well.
Growth of Navigation Role
The promising results of Freeman's1,2 initial navigation program initiated the development of additional patient navigator programs nationally. Many of these programs, although somewhat heterogeneous in their design and implementation, reported success assisting patients through a complex cancer care system.14-19 Program outcomes of navigation in cancer care needed to be defined and rigorously tested.20 Increased interest and requests for financial support of navigation programs created the need for a comprehensive and more rigorous review of navigation methods and outcomes.
In 2002, the National Cancer Institute established funding for the implementation and evaluation of patient navigator programs in cancer care. The primary project is the Patient Navigator Research Program: Eliminating Barriers to Timely Delivery of Cancer Diagnosis and Treatment Services. This program provided funding to 8 institutions nationwide for 5 years "to develop and assess the efficacy and cost-effectiveness of various innovative navigator interventions in communities experiencing cancer health disparities."21Table 1 outlines the location, patient population, navigator characteristics, and specific aims of the National Cancer Institute grantees.
Navigation in Breast Cancer
Cancer navigators are evolving as the cancer care navigation role becomes more defined and delineated in cancer care. Breast cancer is an optimal arena for patient navigation because of known survival benefit of early detection through clinical breast examination, mammography, and early intervention. Navigation is particularly important in breast cancer care because of the documented racial disparity in breast cancer care across the disease trajectory. The 5-year mortality rate after a first diagnosis of breast cancer is 90% for white women, but only 77% for black women.22
The historic explanation for the survival disparity among African American women is late-stage presentation of breast cancer23,24 due to poor adherence to recommended screening tests or nonreporting of clinical symptoms. However, reviews of US cancer studies have also found strong evidence that white patients receive more aggressive initial treatment for breast cancers than do black patients, resulting in higher mortality among the nonwhite populations.25-27 In addition, in the only identified analysis of specifically appointment adherence during systemic breast-cancer therapy, black women were overly represented among women who missed appointments,28 and a greater number of missed appointments correlated with shorter survival.28 Consequently, despite other potential etiologies, there is an increasing need to consider navigation, not only in early detection, but also throughout the breast cancer treatment trajectory.
Navigation is also necessary in breast cancer care to coordinate the multidisciplinary providers and complexity of care across the disease trajectory inherent in breast cancer treatment, including advanced breast cancer.29 Bickell and Young30 described 67 interviews of care providers for early-stage breast cancer patients who described many efforts toward coordination of care for women with early-stage breast cancer, but no consistent methods to track care, receipt of care, or missed appointments. Ongoing research will better inform issues related to role definition, integration into clinical breast cancer care, impact on quality of life, cost-effectiveness, and navigation sustainability.
To evaluate the outcomes of patient navigation in breast cancer care, a comprehensive review of empiric literature detailing the efficacy of breast cancer navigation on outcomes related specifically to breast cancer care (screening, diagnosis, treatment, quality-of-life survivorship, and participation in clinical research) was performed.
Design and Methods
This is a descriptive study of published research evaluating the efficacy of breast cancer navigators and navigation in breast cancer across all aspects of the disease trajectory. Published articles were reviewed if included in the scientific literature between January 1990 and April 2009. Literature search was conducted using PubMed and Ovid databases. Search terms, individually and in combination included MeSH (Medical Subject Headings) terms, "patient navigator," "breast cancer," "medically underserved," and "adherence." The literature search was conducted independently by 2 authors for results verification. When reviewing each navigational intervention study, Consolidated Standards of Reporting Trials (CONSORT) guidelines were followed to ensure an accurate and critical appraisal of the design, conduct, and analysis of each research study. The CONSORT encompasses various initiatives developed by the Consort Group to alleviate the problems of reporting of randomized controlled trials.31 The CONSORT checklist items focus on reporting how the trial was designed, analyzed, and interpreted.31Table 2 was created following CONSORT guidelines and describes the setting, intervention characteristics, study design, sample, goal, results, conclusions, and limitations (Table 2).32-43
If a published article was identified under the approved headings, a determination of the content of the article was made through a review of the published abstract. For an article to meet inclusion criteria, the article had to (1) be data based and (2) include measured efficacy of navigation for women with breast cancer at any stage of the disease continuum. Community education efforts were not included.
PubMed and Ovid Internet search engines resulted in 31 articles meeting the search criteria for patient navigator; 7 for patient navigation and breast cancer; 51,255 for adherence; and 838 journal articles for adherence and breast cancer, by MeSH term match. After applying the inclusion criteria, there were 12 data-based articles evaluating patient navigator efficacy in breast cancer. Articles were analyzed according to specific categories including title, author/year, setting, intervention, design, goal, sample size and racial characteristics of sample, results, conclusions, and limitations (Table 2).
Research studies were conducted during the period from 1999 through April 2009. Nine of 12 interventions (75%) were primarily focused on early-stage intervention, with no navigated role extending into metastatic breast cancer treatment. Most studies (8/12 or 66%) included predominantly or large samples of nonwhite women.
The collection of articles reviewed, although heterogeneous in setting, design, and method, yielded similar outcomes with respect to positive adherence to breast screening and diagnostic follow-up. Goals of navigation interventions were follow-up to screening or clinical breast abnormalities.32-35,38-40,42,43 Some interventions successfully incorporated quality-of-life components into the navigated intervention.37,42 The navigation role, whether tested through randomized controlled trial40-42 or through comparison to historic control,32,34,35,38,39 was effective for moving women to desired outcome in the breast cancer treatment trajectory. Two of the navigation interventions (16%) were nontraditional. One intervention assisted women with only the emotional aspects of a breast cancer diagnosis,37 and another used the navigation role to encourage women to follow through with genetic assessment, rather than tumor evaluation or treatment.41
Clearly, the review of navigation efficacy indicates a positive trend toward adherence to breast cancer screening, follow-up of diagnostic abnormalities, initiation of breast cancer treatment, and stability or improvement in quality of life with patient navigation in breast cancer. These results are encouraging, yet there is still a great deal to pursue in the research agenda. Research design overall is still not appropriately rigorous. Only 3 of the 12 studies were a randomized, controlled design.40-42 Regardless of design, power analysis was not included in any reporting.
Navigation influence can be heavily personally influenced through the strength of an engaging personality. All of the interventions required individuals to deliver the intervention. The interpersonal or "indirect" effect on the interpersonal relationship needs to be separated from the navigation intervention to understand the effects of the individual components of the navigation intervention. The individual navigator's personality and warmth may be an important, integral component of the navigation's success, but it is important to discern if the relationship between the navigator and patient is a direct, quantifiable effect (and measurement tools used to quantify) or an indirect effect of the intervention. These delineations are important for analysis and for dissemination into routine clinical practice.
In addition, few reviews detailed or evaluated the role of navigation through breast cancer treatment, including surgery, chemotherapy, and radiation therapy, and/or long-term hormonal therapy. In addition, all studies concentrated on nonmetastatic breast cancer. Concentrating all navigation research in early-stage, predominantly diagnostic settings does not address the potential navigation needs of women with more advanced-stage illness, women receiving chronic breast-cancer therapy, or women reluctant to finish initial treatment.
Although heterogeneous in location, each of the studies had settings that provided accessible and affordable breast cancer screening and follow-up support to women in predominantly minority, urban, and socioeconomically disadvantaged areas. Each particular study and setting had a unique goal with respect to navigational intervention for women undergoing breast cancer screening. Despite different goals and settings, independent results of each study illustrate similar outcomes. The most compelling is the documented or potential value of accessible, affordable, and supportive breast navigation services across breast cancer settings. These studies were conducted in predominantly minority and economically underserved areas, many in urban cancer centers (10/12 studies), and may be an important intervention toward reducing breast cancer outcome disparity for underserved populations. Interventions using navigation for optimal breast cancer outcomes should be extended to rural settings.
The role of the patient navigator in these studies (Table 2), although heterogeneous, always involved coordination or encouragement toward further care. The roles varied in the scope and the attention toward an emotional or quality-of-life component. More information is desired. The extent of the protocol of the navigator role was not well described in any study. For example, we do not know of a script or an algorithm of response in the encouragement components of the interventions. These data could be helpful for further analysis or replication of the navigator role. The navigator characteristics were not always addressed.32,34,36,38 Despite literature supporting the importance of survivors and race-matched interventionists,2-4 navigators seemed to be effective without meeting all traditional criteria (member of the community they intend to serve and cancer survivor).2 None of the studies specifically identified the navigators as being race matched. Two studies35,37 used breast cancer survivors in a navigator role. When described, most navigation roles were nonhealthcare professionals educated for a primarily supportive, co-coordinating role.39-41 Importantly, the cost of the navigation role/patient benefit was not discussed. The lack of attention to the cost of navigation will limit its clinical usefulness.
There are several limitations to this review of navigational research. First, concentrating all navigational research in early-stage breast cancer does not address the potential navigational needs of women with more advanced breast cancer. Further research directed at examining navigational interventions for women with advanced breast cancer status is necessary.
The extent of the navigation protocol was not well described in any study. It would be beneficial to review summarized navigation scripts and protocols to analyze the institutional resources and personnel expertise needed to replicate successful navigational interventions.
Implications for Nursing
Disparities in healthcare access extend beyond race/ethnicity and sex and include age, socioeconomic status, disability, geographic location, and sexual orientation. One important consideration for nursing is the coordination of navigation services with ongoing care. A lay community member involved in counseling and coordination of services may add complexity to an already complex breast caner care plan. Nursing needs input into navigation training, evaluation, and development of care protocols to ensure that patients are provided accurate, streamlined, evidence-based care.
There are important considerations in the evaluation of patient navigation in breast cancer care. First, it appears that navigation is an effective encouragement for women to advance through breast cancer screening into further diagnostic evaluation and even into breast cancer treatment. More scientific rigor in navigation evaluation is necessary. Additional retrospective research quantifying the risk of diagnostic and treatment delay to specific breast cancer outcomes including survival is needed across the breast cancer treatment trajectory. These findings will likely validate the justification for the navigation role. The important question of breast cancer navigation efficacy in encouraging adherence to breast cancer treatment is unanswered.
In addition, although the results of patient navigation in cancer care are generally positive, the results need to be demarcated according to race, income, disease stage, and other important demographic characteristics so that the efficacy of patient navigation in breast cancer can be delineated according to specific population groups. Ongoing and future research will detail the roles of navigation throughout the breast cancer continuum and continue to strengthen research design for optimal evaluation and utilization of patient navigation programs.
Lastly, it is very important to note that the addition of the role of patient navigation in breast cancer does not adequately address the larger issues of cancer care disparity, complexity, and fragmentation of cancer care. Navigation is a "Band-Aid" rather than a solution to the larger healthcare issues, particularly lack of equal access in cancer care. In a 2001 report to the president, "Voices of a Broken System: Real People, Real Problems," Freeman and Reuben44 acknowledged the value of the navigator role in cancer care by advocating for community-based programs, including patient navigator programs, that help people obtain cancer information, screening, treatment, and supportive services.42 It appears that navigation is effective in encouraging appropriate breast cancer care in many diverse settings and for many populations. Further research should be encouraged.
1. Freeman HP. Patient navigation: a community centered approach to reducing cancer mortality. J Cancer Educ
. 2006;21(1 suppl):S11-S14.
2. Freeman HP. Patient navigation: a community based strategy to reduce cancer disparities. J Urban Health
3. Freeman HP, Muth BJ, Kerner JF. Expanding access to cancer screening and clinical follow-up among the medically underserved. Cancer Pract
4. Hopkins J, Mumber MD. Patient navigation through the cancer care continuum: an overview. J Oncol Pract.
5. Schwaderer K, Itano J. Bridging the healthcare divide with patient navigation: development of a research program to address disparities [online]. Clin J Oncol Nurs
6. Phillips JM. Breast cancer and African American women: moving beyond fear, fatalism, and silence. Oncol Nurs Forum
7. Kinney AY, Emery G, Dudley WN, Croyle RT. Screening behaviors among African American women at high risk for breast cancer: do beliefs about god matter? Oncol Nurs Forum
8. Holt CL, Clark EM, Kreuter MW, Rubio DM. Spiritual health locus of control and breast cancer beliefs among urban African American women. Health Psychol
9. Mayo RM, Ureda JR, Parker VG. Importance of fatalism in understanding mammography screening in rural elderly women. J Women Aging
10. Thomas E. Ring of silence: African American women's experiences related to their breast and breast cancer screening. Qual Rep
11. Phillips JM, Cohen MZ, Moses G. Breast cancer screening and African American women: fear, fatalism, and silence. Oncol Nurs Forum
12. Ashwing G, Ganz PA. Understanding the breast cancer experience of African American women. J Psychosoc Oncol
13. Boardman JD. Health pessimism among black and white adults: the role of interpersonal and institutional maltreatment. Soc Sci Med
14. Weinrich SP, Boyd MD, Weinrich M, Greene F, Reynolds WA, Metlin C. Increasing prostate cancer screening in African American men with peer-educator and client-navigator interventions. J Cancer Educ
15. Freeman HP, Chu KC. Determinants of cancer disparities: barriers to cancer screening, diagnosis, and treatment. Surg Oncol Clin N Am
16. Till JE. Evaluation of support groups for women with breast cancer: importance of the navigator role. Health Qual Life Outcomes
17. Jandorf L, Gutierrez Y, Lopez J, Christie J, Itzkowitz SH. Use of a patient navigator to increase colorectal cancer screening in an urban neighborhood health clinic. J Urban Health
18. Lantz PM, Keeton K, Romano L, Degroff A. Case management in public health screening programs: the experience of the national breast and cervical cancer early detection program. J Public Health Manag Pract
19. Hiatt RA, Pasic RJ, Stewart S, et al. Community-based cancer screening for underserved women: design and baseline findings from the Breast and Cervical Cancer Intervention Study. Prev Med
20. Dohan D, Schrag D. Using navigators to improve care of underserved patients. Current practices and approaches. Cancer
22. American Cancer Society. Breast Cancer Facts and Figures. 2007-2008
. Atlanta, GA: American Cancer Society Inc; 2007.
23. Lanin D, Mathews M, Swanson M, Swanson F, Edwards M. Influence of socioeconomic and cultural factors on racial differences in late stage presentation in breast cancer. JAMA
24. National Cancer Data Base. Patterns of diagnosis and treatment, 1995-2000. National Cancer Institute. http://www.cancer.gov/newscenter
. Accessed September 24, 2007.
25. Shavers V, Brown M. Racial and ethnic disparities in the receipt of cancer treatment. J Natl Cancer Inst
26. Maly R, Umezawa Y, Ratliff C. Racial/ethnic group differences in <?tpor0?>treatment decision-making and treatment received among older breast carcinoma patients. Cancer
27. Du W, Simon M. Racial disparities in treatment and survival of women with stage I-III breast cancer at a large academic medical center in metropolitan Detroit. Breast Cancer Res Treat
28. Howard DL, Penchansky R, Brown MB. Disaggregating the effects of race on breast cancer survival. Fam Med
29. Susman E. Navigating through the questions, choices and conflicting emotions of advanced breast cancer. Oncol Times
30. Bickell N, Young G. Coordination of care for early stage breast cancer patients. J Gen Intern Med
32. Frelix GD, Rosenblatt R, Soloman M, Vikram B. Breast cancer screening in underserved women in the Bronx. J Natl Med Assoc
33. Ell K, Padgett D, Vourlekis B, et al. Abnormal mammogram follow up: a pilot study in women with low income. Cancer Pract
34. Oluwole SF, Ali AO, Adu A, et al. Impact of a cancer screening program on breast cancer stage at diagnosis in a medically underserved urban community. J Am Coll Surg
35. Psooy BJ, Schreuer D, Borgaonkar J, Caines JS. Patient navigation: improving timeliness in the diagnosis of breast abnormalities. Can Assoc Radiol J
36. Donnell S, Leitch AM, Rice D, et al. Navigator program for breast cancer trial recruitment and enrollment at a county hospital. J Clin Oncol
. 2005;23(16S, June suppl):598.
37. Giese Davis J, Bliss-Isberg C, Carson K, et al. The effect of peer counseling on quality of life following diagnosis of breast cancer: an observational study. Psychooncology
38. Allgood KL, Whitman S, Rinder M. Patient navigation in breast health services: improving quality of services at a safety net hospital in Chicago. November 3-7, 2007. Abstract 155690. Presented at the APHA: American Public Health Association 135th Annual Meeting, Scientific Session; Washington, DC.
39. Battaglia TA, Roloff K, Posner MA, Freund KM. Improving follow-up to abnormal breast cancer screening in an urban population. A patient navigation intervention. Cancer
. 2007;109(2 suppl):359-367.
40. Ell K, Vourlekis B, Pey-Jiuan L, Bin X. Patient navigation and case management following an abnormal mammogram: a randomized clinical trial. Prev Med
41. Rahm A, Sukhanova A, Ellis J, Mouchawar J. Increased utilization of cancer genetic counseling services using a patient navigator model. J Genet Couns
42. Ferrante JM, Chen PH, Kim S. The effect of patient navigation on time to diagnosis, anxiety, and satisfaction in urban minority women with abnormal mammograms: a randomized controlled trial. J Urban Health
43. Gabram SG, Lund MJ, Gardner J, et al. Effects of an outreach and internal navigation program on breast cancer diagnosis in an urban cancer center with a large African American population. Wiley InterScience
. Accessed October 22, 2007. 602-607.
44. Freeman HP C. Voices of a broken system: real people, real problems. In: Reuben S, ed. President's Cancer Panel: report of the chairman, 2000-2001.
Bethesda, MD: National Cancer Institute, National Institutes of Health; 2002.
© 2010 Lippincott Williams & Wilkins, Inc.