Improvements in burn wound care have vastly decreased morbidity and mortality in severely burned patients. Development of new therapeutic approaches to increase wound repair has the potential to reduce infection, graft rejection, and hypertrophic scarring. The incorporation of tissue-engineering techniques, along with the use of exogenous proteins, genes, or stem cells to enhance wound healing, heralds new treatment regimens based on the modification of already existing biological activity. Refinements to surgical techniques have enabled the creation of protocols for full facial transplantation. With new technologies and advances such as these, care of the severely burned will undergo massive changes over the next decade. This review centers on new developments that have recently shown great promise in the investigational arena.
From the *University of Toronto; †Department of Surgery, Division of Plastic Surgery, ‡Department of Immunology, and §Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre; ‖Sunnybrook Research Institute; ¶Department of Surgery, Sealy Center for Molecular Medicine, and the Institute for Translational Science, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston; and #Department of Plastic and Reconstructive Surgery, Hannover Medical School, Germany.
This work is supported by grants to M.G. Jeschke from the National Institutes of Health (R01 GM087285), CFI Leader’s Opportunity Fun (Project 25407), Canadian Institutes of Health Research 123336, and Physicians’ Services Incorporated Foundation—Health Research Grant Program as well as to C.C. Finnerty from the Shriners Hospitals for Children (8740, 71001) and the 3M Wound Healing Foundation Award. C.C. Finnerty is an ITS Career Development Scholar supported, in part, by National Institutes of Health (NIH) KL2RR029875 and NIH UL1RR029876.
Address correspondence to Marc G. Jeschke, MD, PhD, Division of Plastic Surgery, Department of Surgery, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Sunnybrook Research Institute, Rm D704, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada.