Skip Navigation LinksHome > September/October 2009 - Volume 30 - Issue 5 > Supplementation of Vitamin E, Vitamin C, and Zinc Attenuates...
Journal of Burn Care & Research:
doi: 10.1097/BCR.0b013e3181b487a8
Original Articles

Supplementation of Vitamin E, Vitamin C, and Zinc Attenuates Oxidative Stress in Burned Children: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Barbosa, Eliana RD, MS*†; Faintuch, Joel MD, PhD‡; Machado Moreira, Emilia Addison RD, PhD*; Gonçalves da Silva, Viviane Rodrigues RD*; Lopes Pereima, Maurício José MD, PhD†§; Martins Fagundes, Regina Lúcia RD, PhD*; Filho, Danilo Wilhelm PhD¶

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Abstract

The aim of this study was to investigate the effect of supplementation of vitamin E, vitamin C, and zinc on the oxidative stress in burned children. In a prospective double-blind placebo-controlled pilot study, 32 patients were randomized as no supplementation (n = 15) or antioxidant supplementation (n = 17) groups. Supplementation consisted of the antioxidant mixture of vitamin C (1.5 times upper intake level), vitamin E (1.35 times upper intake level), and zinc (2.0 times recommended dietary allowance) administered during 7 days starting on the second day of admittance into the hospital. Energy requirement was calculated by the Curreri equation, and protein input was 3.0 g/kg of ideal body mass index (percentile 50°). Total antioxidant capacity of plasma and malondialdehyde were used to monitor oxidative stress. The time of wound healing was evaluated as the main clinical feature. Patients (age 54.2 ± 48.9 months, 65.6% males), who exhibited 15.5 ± 6.7% of total burn area, showed no differences in age and sex, when compared with controls. Intake of the administered antioxidants was obviously higher in treated subjects (P = .005), and serum differences were confirmed for vitamin E and C, but not for zinc (P = .180). There was a decrease in lipid peroxidation (malondialdehyde level) (P = .006) and an increase in vitamin E concentrations in the antioxidant supplementation group (P = .016). The time of wound healing was lower in the supplemented group (P < .001). The antioxidant supplementation through vitamin E and C and the mineral zinc apparently enhanced antioxidant protection against oxidative stress and allowed less time for wound healing.

© 2009 The American Burn Association

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