A second potential therapeutic option for the parenchymal damage caused by inhalation injury is systemic administration of intravenous agents. The unique nature of the effects of the burn and smoke on lung physiology and immunology create new opportunities for systemic treatments targeting specific aspects of the response to injury. In addition, systemic therapies could be either isolated or combined with inhalation therapies to achieve optimal clinical response. The two articles in this section of the compendium address different, yet promising, systemic therapies: antithrombin and vitamin C.
From the Department of Surgery, University of Texas Health Science Centre, San Antonio; and United States Army Institute of Surgical Research, Fort Sam Houston, Texas.
This study was supported by a Grant 8431 from Shriners Hospital for Children.
Address correspondence to Steven E. Wolf, MD, Department of Surgery, University of Texas Health Science Centre, San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78286-3900.