Skip Navigation LinksHome > July/August 2006 - Volume 27 - Issue 4 > Livedoid Dermatitis and Severe Necrosis (Nicolau’s Syndrome)...
Journal of Burn Care & Research:
doi: 10.1097/01.BCR.0000225917.09339.03
Case Reports

Livedoid Dermatitis and Severe Necrosis (Nicolau’s Syndrome) After Intramuscular Hydroxyzine Injection

Gayken, Jon MD*; Westanmo, Anders PharmD*; Knutsen, Amy MD†; Ahrenholz, David H. MD†; Mohr, William J. III MD†; Solem, Lynn D. MD†

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Nicolau’s syndrome, also called embolica cutis medicamentosa, is characterized by well- circumscribed livedoid dermatitis with aseptic necrosis after intramuscular injection. We report the case of a 45-year-old woman with severe necrosis of the thigh several days after a routine intramuscular injection of hydroxyzine who was transferred to and treated at our Regional Burn Center. Although there has been one case report and numerous voluntarily reported instances of intramuscular hydroxyzine-induced necrosis to the Food and Drug Administration Spontaneous Reporting System, this phenomenon is rare.

© 2006 The American Burn Association


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