A 15-year-old nonsmoking adolescent visited our hospital with complaints of cough and hemoptysis. Chest imaging detected a dense consolidation located in right middle and lower lobes. Bronchoscopy revealed a bulging mass into the right main bronchus. Biopsies of the lesion were diagnostic for Langerhans' cell histiocytosis. There were no features of interstitial lung disease. The patient was suffering a multifocal disease since additional lesions were detected in stomach and duodenum. This case is unique in its presentation with endobronchial involvement as part of histologically proven multifocal Langerhans' cell histiocytosis. Furthermore, positron emission tomography scan turned out to be a useful tool for the diagnosis and follow-up.